Asian Journal of Research in Chemistry

Tiwari Preeti ¹, R. K. Patel ²

Affiliations
1 Department of Pharmacognosy, Shri Sarvajanik Pharmacy College, Mehsana-384001 (N. Gujarat), IN
2 Department of Pharmacognosy, Shri. S. K. Patel College of Pharmaceutical Education and Research, Kherva-382711 (N. Gujarat), IN

Abstract

The present study was carried out to compare the lipid peroxidation activity and related hypolipidaemic activity in Arjunarishta-T and Arjunarishta-M prepared by traditional and modern methods with standard Atorvastatin. Hypolipidaemic activity was evaluated on cholesterol fed rats. The antioxidant activity of Arjunarishta-T and Arjunarishta-M was increased in a concentration dependent manner. Arjunarishta-T and Arjunarishta-M inhibited the ferrous sulphate induced lipid peroxidation in a dose dependent manner and showed Inhibitory Concentration (IC₅₀) value 195.60 and 197.77 μl/ml, respectively. In hypolipidemic activity Arjunarishta-T and Arjunarishta-M at the dose of 2.0 ml/kg body weight orally significantly reduced serum cholesterol (45% and 43%), serum LDL (61% and 58%) and serum triglycerides (35% and 34%). The increase in HDL was 17% when compared to control with both the Arjunarishta T and M and reduction in atherogenic index was found 1.393 and 1.494 in Arjunarishta-T and Arjunarishta-M treated groups respectively, which strongly supports anti-atherosclerotic property of Arjunarishta.

Keywords

Arjunarishta, Lipid Peroxidation, Atherogenic Index, Anti-Hyperlipidemic Activity.

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Tiwari Preeti ¹, R. K. Patel ²

Affiliations
1 Department of Pharmacognosy, Shri Sarvajanik Pharmacy College, Mehsana-384001 (N. Gujarat), IN
2 Department of Pharmacognosy, Shri. S. K. Patel College of Pharmaceutical Education and Research, Kherva-382711 (N. Gujarat), IN

Abstract

The present study was carried out to compare the lipid peroxidation activity and related hypolipidaemic activity in Ashwagandhrishta-T and Ashwagandhrishta-M prepared by traditional and modern methods with standard Atorvastatin. Hypolipidaemic activity was evaluated on cholesterol fed rats. The antioxidant activity of Ashwagandharishta-T and Ashwagandharishta-M was increased in a concentration dependent manner. Ashwagandharishta-T and Ashwagandharishta-M inhibited the ferrous sulphate induced lipid per-oxidation in a dose dependent manner and showed inhibitory concentration (IC₅₀) value 181.88 and 191.05 μl/ml, respectively. In hypolipidemic activity Ashwagandharishta-T and Ashwagandharishta-M at the dose of 2.0 ml/kg body weight orally significantly reduced serum cholesterol (47% and 46%), serum LDL (66% and 65%), and serum triglycerides (35% and 34%). The increase in serum HDL was 19% when compared to control with both the Ashwagandharishta T and M and reduction in atherogenic index was found 1.25 and 1.29 in Ashwagandharishta-T and Ashwagandharishta-M treated groups respectively, which strongly supports anti-atherosclerotic property of Ashwagandharishta.

Keywords

Ashwagandharishta, Lipid Per-Oxidation, Atherogenic Index, Anti-Hyperlipidemic Activity.

Full Text

     

Tiwari Preeti ¹, R. K. Patel ²

Affiliations
1 Department of Pharmacognosy, Shri Sarvajanik Pharmacy College, Mehsana-384001, (N.G), IN
2 Shri. S.K. Patel College of Pharmaceutical Education and Research, Kherva, Mehsana, (N.G), IN

Abstract

The objective of the study was to evaluate the chances of reduction in cardiovascular risk factors associated with diabetic conditions. Both type of Arjunarishta-T and Arjunarishta-M, were prepared by traditional and modern methods, respectively, and evaluated on fasting blood sugar, blood glutathione levels and serum biochemical parameters in alloxan induced diabetes. Both the Arjunarishta preparations were able to maintain the tested parameters near to normal level significantly.

Keywords

Cardiovascular Risk, Antidiabetic, Arjunarishta, Glutathione.

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